Bradley R. Cairns

Bradley R. Cairns, PhD

Languages spoken: English

Academic Information

Departments Primary - Oncological Sciences , Adjunct - Biochemistry

Lab

Research Interests

  • Cancer Biology
  • Chromatin
  • Transcription Factors
  • DNA Methylation
  • Zebrafish

Dr. Bradley R. Cairns serves as CEO of Huntsman Cancer Institute, a nationally recognized cancer research center and hospital, with extensive programs engaging communities, serving students, and advancing cancer education efforts.

Cairns is a pioneering molecular biologist whose research has transformed our understanding of gene packaging and gene expression, also termed epigenetics, in development and cancer. He earned his B.S. in Chemistry from Lewis and Clark College in 1987, followed by a Ph.D. in Cell Biology from Stanford University in 1996, where he trained under Nobel Laureate Roger Kornberg. His postdoctoral work included fellowships at Stanford and Harvard Medical School, focusing on genetic and genome approaches to gene packaging.

In 1998, Dr. Cairns joined the University of Utah’s Department of Oncological Sciences and Huntsman Cancer Institute. He was selected as a Howard Hughes Medical Institute Investigator in 2000. He has served in a number of major leadership capacities at the University of Utah and Huntsman Cancer Institute. These include Senior Director of Basic Science (2010-2020); and Chief Academic Officer (2020-present) at Huntsman Cancer Institute; as well as chair of the Molecular Biology Graduate Program (2008-2011), Chair of the Department of Oncological Sciences (2013-2025), American Association for Cancer Research Science Policy and Government Affairs Committee (2025-2026), and various national and international scientific advisory boards.

Dr. Cairns was the first to purify gene packaging complexes such as SWI/SNF and RSC, revealing how these molecular machines unpack genes to enable expression—a process disrupted in 20% of all cancers. His lab has made landmark discoveries in germline gene packaging and epigenetics, identifying how developmental genes are poised for activation in embryos as well as characterizing the long-sought undifferentiated human spermatogonial stem cells

His research spans multiple model organisms—yeast, zebrafish, mice, and humans—and integrates biochemistry, genetics, and genomics to explore epigenetic regulation. His work has illuminated how epigenetic dynamics govern totipotency in early embryos and how these mechanisms are misregulated in cancer

Dr. Cairns is deeply committed to mentorship and inclusion, having trained over 25 graduate students and numerous postdoctoral fellows. Key initiatives under his oversight included the establishment of the Leadership Excellence Advancement and Development (LEAD) Program. LEAD joins together cohorts of clinical investigators, cancer research scientists, and senior staff leaders to foster growth in leadership skills designed to advance the culture and impact of Huntsman Cancer Institute. Cairns also spearheaded the organization of scientific and experiential learning programs at HCI that involved partnership with trainees from Brigham Young University and Utah Valley University, designed to enhance pathways for more Utah students to prepare for the future health and research workforce. These include the Huntsman Cancer Institute-Utah Valley University Health Collaborative, which provides experiential learning through work opportunities in cancer research. Also, he initiated two endeavors with Brigham Young University: one engages biomedical informatics students from BYU in cancer-focused capstone projects utilizing methods including artificial intelligence and data science; the other provides full-time summer research opportunities in an array of cancer research areas.

In recognition of his scientific contributions, Cairns was elected as a Fellow of the Royal Society, the world’s oldest science academy, and as a Fellow of the American Academy of Arts and Sciences.

Research Statement

Cancer is a disease involoving improper cell growth, death and differentiation. My research focuses on determining - at the mechanistic level - how a cell normally regulates processes important to cancer such as chromatin structure, transcription, and developmental decisions.
Research: The Cairns lab strives to understand chromatin-transcription relationships – with an emphasis on development and cancer – and effectively utilizes biochemistry, genetics, and genomics in multiple model systems. The areas/questions the lab addresses include 1) Chromatin remodeling: How are nucleosomes moved and ejected by chromatin-remodeling complexes, and how is this progress misregulated in cancer? 2) Germline and embryo gene packaging: Are genes important for embryo development (and oncogenesis) packaged in special chromatin structures while in the germline and what is their fate and impact in the early embryo? 3) How is Totipotency – the ability to become any cell type – established in early cleavage-stage embryos, and are the factors involved misregulated in cancer? 4) How does the genome ‘sculpt’ chromatin structure to achieve proper gene regulation prior to the onset of transcription in embryos.

Education History

Postdoctoral Fellowship Harvard Medical School - Fred Winston, PhD
 Postdoctoral Fellow
Postdoctoral Fellowship Stanford University - Roger Kornberg, PhD
 Postdoctoral Fellow
Doctoral Training Stanford University - Roger Kornberg, PhD
 PhD
Undergraduate Lewis and Clark College
 BS

Selected Publications

Journal Article

  1. Shi J, Zhang X, Cai C, Liu S, Yu J, James ER, Liu L, Emery BR, McMurray Bires MR, Torres-Arce E, Rawal HC, Ramsay J, Kunisaki J, Zhou C, Milstone DS, Patti ME, Yang X, Jenkins TG, Quinlan A, Cairns BR, Schimmel P, Hotaling JM, Aston KI, Zhou T, Chen Q (2026). Conserved shifts in sperm small non-coding RNA profiles during mouse and human aging. EMBO J, 45(4), 1362-1380.
  2. Sotiriou A, Li J, Middha S, Ward JA, Troester S, Mao L, Schneider M, Frey D, Wray EC, Bocedi S, Smith-Fry K, Morrison L, Carroll L, Badonyi M, Marsh JA, Jayavelu AK, Mayor-Ruiz C, Cairns BR, Jones KB, Benabdallah NS, Banito A (2026). BAF complex-independent gene activation by SS18::SSX. bioRxiv.
  3. Li J, Li L, Smith-Fry K, Fadlullah MZ, Carroll L, Morrison L, Ge X, Nelson ML, Hill LA, Guo Y, Davenport G, Zhang X, Nielsen TO, Hirst M, Underhill TM, Cairns BR, Jones KB (2025). Synovial sarcoma reprograms transcription by GBAF activation of polycomb targets and loss of CBAF enhancers. Nat Commun, 17(1), 1081.
  4. Feng BJ, Kohlmann W, Nix DA, Atkinson A, Boucher KM, Carroll C, Stubben CJ, Kolesar J, Singer EA, Riedlinger G, Edge S, Sahu KK, Churchman M, Graham L, Salhia B, Sanchez A, Zakharia Y, Schneider BP, Jain R, Byrne L, Moskaluk CA, Nepple K, Shabsigh A, Chahoud J, Cairns BR, Gupta S (2025). Germline whole-exome sequencing reveals FOXP3-related gene variants conferring urinary cancer susceptibility and associated with immune escape. J Immunother Cancer, 13(9).
  5. Yi C, Kitamura Y, Maezawa S, Namekawa SH, Cairns BR (2025). ZBTB16/PLZF regulates juvenile spermatogonial stem cell development through an extensive transcription factor poising network. Nat Struct Mol Biol, 32(7), 1213-1226.
  6. Jiang Q, Cui L, Nie X, Cai H, Zhang W, Lu X, Guo Y, Hotaling JM, Cairns BR, Wang X, Guo J (2025). A Single-Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging. Aging Cell, 24(6), e70032.
  7. Cui L, Nie X, Guo Y, Ren P, Guo Y, Wang X, Li R, Hotaling JM, Cairns BR, Guo J (2025). Single-cell transcriptomic atlas of the human testis across the reproductive lifespan. Nat Aging, 5(4), 658-674.
  8. Shen Z, Wu Y, Manna A, Yi C, Cairns BR, Evason KJ, Chandrasekharan MB, Tantin D (2024). Oct4 redox sensitivity potentiates reprogramming and differentiation. Genes Dev, 38(7-8), 308-321.
  9. Wamaitha SE, Nie X, Pandolfi EC, Wang X, Yang Y, Stukenborg JB, Cairns BR, Guo J, Clark AT (2023). Single-cell analysis of the developing human ovary defines distinct insights into ovarian somatic and germline progenitors. Dev Cell, 58(20), 2097-2111.
  10. Smith CM, Grow EJ, Shadle SC, Cairns BR (2023). Multiple repeat regions within mouse DUX recruit chromatin regulators to facilitate an embryonic gene expression program. bioRxiv.
  11. Wang X, Cairns BR, Guo J (2022). When spermatogenesis meets human aging and elevated body mass. Life Med, 1(3), 267-269.
  12. Nie X, Munyoki SK, Sukhwani M, Schmid N, Missel A, Emery BR, DonorConnect, Stukenborg JB, Mayerhofer A, Orwig KE, Aston KI, Hotaling JM, Cairns BR, Guo J (2022). Single-cell analysis of human testis aging and correlation with elevated body mass index. Dev Cell, 57(9), 1160-1176.e5.
  13. Sun W, Guo J, McClellan D, Poeschla A, Bareyan D, Casey MJ, Cairns BR, Tantin D, Engel ME (2022). GFI1 Cooperates with IKZF1/IKAROS to Activate Gene Expression in T-cell Acute Lymphoblastic Leukemia. Mol Cancer Res, 20, 501-514.
  14. Chen H, Murray E, Sinha A, Laumas A, Li J, Lesman D, Nie X, Hotaling J, Guo J, Cairns BR, Macosko EZ, Cheng CY, Chen F (2020). Dissecting mammalian spermatogenesis using spatial transcriptomics. Cell Rep, 37(5), 109915.
  15. Grow EJ, Weaver BD, Smith CM, Guo J, Stein P, Shadle SC, Hendrickson PG, Johnson NE, Butterfield RJ, Menafra R, Kloet SL, van der Maarel SM, Williams CJ, Cairns BR (2021). p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models. Nat Genet, 53(8), 1207-1220.
  16. Li J, Mulvihill TS, Li L, Barrott JJ, Nelson ML, Wagner L, Lock IC, Pozner A, Lambert SL, Ozenberger BB, Ward MB, Grossmann AH, Liu T, Banito A, Cairns BR, Jones KB (2021). A Role for SMARCB1 in Synovial Sarcomagenesis Reveals That SS18-SSX Induces Canonical BAF Destruction. Cancer Discov, 11(10), 2620-2637.
  17. Wike CL, Guo Y, Tan M, Nakamura R, Shaw DK, Daz N, Whittaker-Tademy AF, Durand NC, Aiden EL, Vaquerizas JM, Grunwald D, Takeda H, Cairns BR (2021). Chromatin architecture transitions from zebrafish sperm through early embryogenesis. Genome Res, 31(6), 981-994.
  18. Nakamura R, Motai Y, Kumagai M, Wike CL, Nishiyama H, Nakatani Y, Durand NC, Kondo K, Kondo T, Tsukahara T, Shimada A, Cairns BR, Aiden EL, Morishita S, Takeda H (2021). CTCF looping is established during gastrulation in medaka embryos. Genome Res, 31(6), 968-980.
  19. Guo J, Sosa E, Chitiashvili T, Nie X, Rojas EJ, Oliver E, DonorConnect, Plath K, Hotaling JM, Stukenborg JB, Clark AT, Cairns BR (2021). Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment. Cell Stem Cell, 28(4), 764-778.e4.
  20. Shi J, Zhang Y, Tan D, Zhang X, Yan M, Zhang Y, Franklin R, Shahbazi M, Mackinlay K, Liu S, Kuhle B, James ER, Zhang L, Qu Y, Zhai Q, Zhao W, Zhao L, Zhou C, Gu W, Murn J, Guo J, Carrell DT, Wang Y, Chen X, Cairns BR, Yang XL, Schimmel P, Zernicka-Goetz M, Cheloufi S, Zhang Y, Zhou T, Chen Q (2021). PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications. Nat Cell Biol, 23(4), 424-436.
  21. DOrazio FM, Balwierz PJ, Gonzlez AJ, Guo Y, Hernndez-Rodrguez B, Wheatley L, Jasiulewicz A, Hadzhiev Y, Vaquerizas JM, Cairns B, Lenhard B, Mller F (2021). Germ cell differentiation requires Tdrd7-dependent chromatin and transcriptome reprogramming marked by germ plasm relocalization. Dev Cell, 56(5), 641-656.e5.
  22. Tharmalingam MD, Matilionyte G, Wallace WHB, Stukenborg JB, Jahnukainen K, Oliver E, Goriely A, Lane S, Guo J, Cairns B, Jorgensen A, Allen CM, Lopes F, Anderson RA, Spears N, Mitchell RT (2020). Cisplatin and carboplatin result in similar gonadotoxicity in immature human testis with implications for fertility preservation in childhood cancer. BMC Med, 18(1), 374.
  23. Clapier CR, Verma N, Parnell TJ, Cairns BR (2020). Cancer-Associated Gain-of-Function Mutations Activate a SWI/SNF-Family Regulatory Hub. Mol Cell, 80(4), 712-725.e5.
  24. Murphy PJ, Guo J, Jenkins TG, James ER, Hoidal JR, Huecksteadt T, Broberg DS, Hotaling JM, Alonso DF, Carrell DT, Cairns BR, Aston KI (2020). NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure. PLoS Genet, 16(6), e1008756.
  25. Gambini A, Stein P, Savy V, Grow EJ, Papas BN, Zhang Y, Kenan AC, Padilla-Banks E, Cairns BR, Williams CJ (2020). Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation. Dev Cell, 53(5), 545-560.e7.
  26. Schlichter A, Kasten MM, Parnell TJ, Cairns BR (2020). Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes. Elife, 9.
  27. Guo J, Nie X, Giebler M, Mlcochova H, Wang Y, Grow EJ, DonorConnect, Kim R, Tharmalingam M, Matilionyte G, Lindskog C, Carrell DT, Mitchell RT, Goriely A, Hotaling JM, Cairns BR (2020). The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty. Cell Stem Cell, 26(2), 262-276.e4.
  28. Ye Y, Wu H, Chen K, Clapier CR, Verma N, Zhang W, Deng H, Cairns BR, Gao N, Chen Z (2019). Structure of the RSC complex bound to the nucleosome. Science, 366(6467), 838-843.
  29. Rougeot J, Chrispijn ND, Aben M, Elurbe DM, Andralojc KM, Murphy PJ, Jansen PWTC, Vermeulen M, Cairns BR, Kamminga LM (2019). Maintenance of spatial gene expression by Polycomb-mediated repression after formation of a vertebrate body plan. Development, 146(19).
  30. Cakiroglu A, Clapier CR, Ehrensberger AH, Darbo E, Cairns BR, Luscombe NM, Svejstrup JQ (2019). Genome-wide reconstitution of chromatin transactions reveals that RSC preferentially disrupts H2AZ-containing nucleosomes. Genome Res, 29(6), 988-998.
  31. Guo J, Cairns BR (2019). Isolation and Enrichment of Spermatogonial Stem Cells From Human Testis Tissues. Curr Protoc Stem Cell Biol, 49(1), e77.
  32. Khoddami V, Yerra A, Mosbruger TL, Fleming AM, Burrows CJ, Cairns BR (2019). Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution. Proc Natl Acad Sci U S A, 116(14), 6784-6789.
  33. Jenkins TG, Aston KI, Cairns B, Smith A, Carrell DT (2018). Paternal germ line aging: DNA methylation age prediction from human sperm. BMC Genomics, 19(1), 763.
  34. Murphy PJ, Wu SF, James CR, Wike CL, Cairns BR (2018). Placeholder Nucleosomes Underlie Germline-to-Embryo DNA Methylation Reprogramming. Cell, 172(5), 993-1006.e13.
  35. Jenkins TG, James ER, Alonso DF, Hoidal JR, Murphy PJ, Hotaling JM, Cairns BR, Carrell DT, Aston KI (2017). Cigarette smoking significantly alters sperm DNA methylation patterns. Andrology, 5(6), 1089-1099.
  36. Guo J, Grow EJ, Yi C, Mlcochova H, Maher GJ, Lindskog C, Murphy PJ, Wike CL, Carrell DT, Goriely A, Hotaling JM, Cairns BR (2017). Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development. Cell Stem Cell, 21(4), 533-546.e6.
  37. Clapier CR, Iwasa J, Cairns BR, Peterson CL (2017). Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes. Nat Rev Mol Cell Biol, 18(7), 407-422.
  38. Hendrickson PG, Doris JA, Grow EJ, Whiddon JL, Lim JW, Wike CL, Weaver BD, Pflueger C, Emery BR, Wilcox AL, Nix DA, Peterson CM, Tapscott SJ, Carrell DT, Cairns BR (2017). Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons. Nat Genet, 49(6), 925-934.
  39. Jones KB, Barrott JJ, Xie M, Haldar M, Jin H, Zhu JF, Monument MJ, Mosbruger TL, Langer EM, Randall RL, Wilson RK, Cairns BR, Ding L, Capecchi MR (2016). The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis. Oncogene, 35(38), 5021-32.
  40. Ramakrishnan S, Pokhrel S, Palani S, Pflueger C, Parnell TJ, Cairns BR, Bhaskara S, Chandrasekharan MB (2016). Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription. Nat Commun, 7, 11949.
  41. Clapier CR, Kasten MM, Parnell TJ, Viswanathan R, Szerlong H, Sirinakis G, Zhang Y, Cairns BR (2016). Regulation of DNA Translocation Efficiency within the Chromatin Remodeler RSC/Sth1 Potentiates Nucleosome Sliding and Ejection. Mol Cell, 62(3), 453-461.
  42. Hendrickson PG, Cairns BR (2016). Tet proteins enhance the developmental hourglass. Nat Genet, 48(4), 345-7.
  43. Aston KI, Uren PJ, Jenkins TG, Horsager A, Cairns BR, Smith AD, Carrell DT (2015). Aberrant sperm DNA methylation predicts male fertility status and embryo quality. Fertil Steril, 104(6), 1388-97.e1-5.
  44. Huang F, Ramakrishnan S, Pokhrel S, Pflueger C, Parnell TJ, Kasten MM, Currie SL, Bhachech N, Horikoshi M, Graves BJ, Cairns BR, Bhaskara S, Chandrasekharan MB (2015). Interaction of the Jhd2 Histone H3 Lys-4 Demethylase with Chromatin Is Controlled by Histone H2A Surfaces and Restricted by H2B Ubiquitination. J Biol Chem, 290(48), 28760-77.
  45. Hammoud SS, Low DH, Yi C, Lee CL, Oatley JM, Payne CJ, Carrell DT, Guccione E, Cairns BR (2015). Transcription and imprinting dynamics in developing postnatal male germline stem cells. Genes Dev, 29(21), 2312-24.
  46. Parnell T J, Schlicter A, Wilson B G, Cairns B R (Spring 2015). The chromatin remodelers RSC and ISW1 display functional and chromatin-based promoter antagonism. Elife, 4, e06073.
  47. Parnell TJ, Schlichter A, Wilson BG, Cairns BR (2015). The chromatin remodelers RSC and ISW1 display functional and chromatin-based promoter antagonism. Elife, 4, e06073.
  48. Varshney D, Vavrova-Anderson J, Oler AJ, Cowling VH, Cairns BR, White RJ (2015). SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation. Nat Commun, 6, 6569.
  49. Khoddami V, Yerra A, Cairns BR (2015). Experimental Approaches for Target Profiling of RNA Cytosine Methyltransferases. Methods Enzymol, 560, 273-96.
  50. Hammoud SS, Low DH, Yi C, Carrell DT, Guccione E, Cairns BR (2014). Chromatin and transcription transitions of mammalian adult germline stem cells and spermatogenesis. Cell Stem Cell, 15(2), 239-53.
  51. Jenkins TG, Aston KI, Pflueger C, Cairns BR, Carrell DT (2014). Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility. PLoS Genet, 10(7), e1004458.
  52. Nelson AC, Cauceglia JW, Merkley SD, Youngson NA, Oler AJ, Nelson RJ, Cairns BR, Whitelaw E, Potts WK (2013). Reintroducing domesticated wild mice to sociality induces adaptive transgenerational effects on MUP expression. Proc Natl Acad Sci U S A, 110(49), 19848-53.
  53. Potok ME, Nix DA, Parnell TJ, Cairns BR (2013). Reprogramming the maternal zebrafish genome after fertilization to match the paternal methylation pattern. Cell, 153(4), 759-72.
  54. Khoddami V, Cairns BR (2013). Identification of direct targets and modified bases of RNA cytosine methyltransferases. Nat Biotechnol, 31(5), 458-64.
  55. Clapier CR, Cairns BR (2012). Regulation of ISWI involves inhibitory modules antagonized by nucleosomal epitopes. Nature, 492(7428), 280-4.
  56. Oler AJ, Cairns BR (2012). PP4 dephosphorylates Maf1 to couple multiple stress conditions to RNA polymerase III repression. EMBO J, 31(6), 1440-52.
  57. Sirinakis G, Clapier CR, Gao Y, Viswanathan R, Cairns BR, Zhang Y (2011). The RSC chromatin remodelling ATPase translocates DNA with high force and small step size. EMBO J, 30(12), 2364-72.
  58. Wu SF, Zhang H, Cairns BR (2011). Genes for embryo development are packaged in blocks of multivalent chromatin in zebrafish sperm. Genome Res, 21(4), 578-89.
  59. Kasten MM, Clapier CR, Cairns BR (2011). SnapShot: Chromatin remodeling: SWI/SNF. Cell, 144(2), 310.e1.
  60. Rai K, Sarkar S, Broadbent TJ, Voas M, Grossmann KF, Nadauld LD, Dehghanizadeh S, Hagos FT, Li Y, Toth RK, Chidester S, Bahr TM, Johnson WE, Sklow B, Burt R, Cairns BR, Jones DA (2010). DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell, 142(6), 930-42.
  61. Oler AJ, Alla RK, Roberts DN, Wong A, Hollenhorst PC, Chandler KJ, Cassiday PA, Nelson CA, Hagedorn CH, Graves BJ, Cairns BR (2010). Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors. Nat Struct Mol Biol, 17(5), 620-8.
  62. Cairns BR (2009). The logic of chromatin architecture and remodelling at promoters. Nature, 461(7261), 193-8.
  63. Hammoud SS, Nix DA, Zhang H, Purwar J, Carrell DT, Cairns BR (2009). Distinctive chromatin in human sperm packages genes for embryo development. Nature, 460(7254), 473-8.
  64. Rai K, Huggins IJ, James SR, Karpf AR, Jones DA, Cairns BR (2008). DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell, 135(7), 1201-12.
  65. Dutrow N, Nix DA, Holt D, Milash B, Dalley B, Westbroek E, Parnell TJ, Cairns BR (2008). Dynamic transcriptome of Schizosaccharomyces pombe shown by RNA-DNA hybrid mapping. Nat Genet, 40(8), 977-86.
  66. Szerlong H, Hinata K, Viswanathan R, Erdjument-Bromage H, Tempst P, Cairns BR (2008). The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPases. Nat Struct Mol Biol, 15(5), 469-76.
  67. VanDemark AP, Kasten MM, Ferris E, Heroux A, Hill CP, Cairns BR (2007). Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation. Mol Cell, 27(5), 817-28.
  68. Rai K, Chidester S, Zavala CV, Manos EJ, James SR, Karpf AR, Jones DA, Cairns BR (2007). Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish. Genes Dev, 21(3), 261-6.
  69. Soutourina J, Bordas-Le Floch V, Gendrel G, Flores A, Ducrot C, Dumay-Odelot H, Soularue P, Navarro F, Cairns BR, Lefebvre O, Werner M (2006). Rsc4 connects the chromatin remodeler RSC to RNA polymerases. Mol Cell Biol, 26(13), 4920-33.
  70. Roberts DN, Wilson B, Huff JT, Stewart AJ, Cairns BR (2006). Dephosphorylation and genome-wide association of Maf1 with Pol III-transcribed genes during repression. Mol Cell, 22(5), 633-44.
  71. Zhang H, Roberts DN, Cairns BR (2005). Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss. Cell, 123(2), 219-31.
  72. Saha A, Wittmeyer J, Cairns BR (2005). Chromatin remodeling through directional DNA translocation from an internal nucleosomal site. Nat Struct Mol Biol, 12(9), 747-55.
  73. Cairns BR (2004). Around the world of DNA damage INO80 days. Cell, 119(6), 733-5.

Review

  1. Kasten MM, Clapier CR, Cairns BR (2011). SnapShot: Chromatin remodeling: SWI/SNF. [Review]. Cell, 144(2), 310.e.l..

Other

  1. Hickey GJ, Wike CL, Nie X, Guo Y, Tan M, Murphy PJ, Cairns BR (2022). Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos. Elife (11). England.
  2. Shi J, Zhang Y, Tan D, Zhang X, Yan M, Zhang Y, Franklin R, Shahbazi M, Mackinlay K, Liu S, Kuhle B, James ER, Zhang L, Qu Y, Zhai Q, Zhao W, Zhao L, Zhou C, Gu W, Murn J, Guo J, Carrell DT, Wang Y, Chen X, Cairns BR, Yang XL, Schimmel P, Zernicka-Goetz M, Cheloufi S, Zhang Y, Zhou T, Chen Q (2021). Author Correction: PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications. Nat Cell Biol (23(6), p. 676). England.

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