Elliot H. Smith

Elliot H. Smith, PhD

Languages spoken: French, Indonesian, English

Academic Information

Departments Primary - Neurosurgery

Education History

Fellowship Columbia University
 Postdoctoral Training
Doctoral Training University of Utah
 PhD
Undergraduate University of Washington
 BS

Selected Publications

Journal Article

  1. Libowitz MR, Sun W, Rabinovich R, Du J, Campbell JM, Cowan RL, Shahdoust N, Price TA, Davis TS, Buckner RL, Rahimpour S, Mickey BJ, Smith EH, Shofty B (2026). Increased aperiodic exponents track depressive symptom severity in refractory epilepsy. Biol Psychiatry Cogn Neurosci Neuroimaging.
  2. Zarr VM, Davis TS, House PA, Greger B, Davis ZW, Smith EH (2026). Propofol-induced loss of responsiveness reorganizes cortical traveling waves in the human brain. bioRxiv.
  3. Shahdoust N, Cowan RL, Price TA, Davis TS, Liu A, Rabinovich R, Zarr V, Libowitz M, Shofty B, Rahimpour S, Borisyuk A, Smith EH (2026). Asymmetric Reinforcement Learning Explains Human Choice Patterns in Decision-making Under Risk. bioRxiv.
  4. Libowitz MR, Sun W, Rabinovich R, Du J, Campbell JM, Cowan RL, Shahdoust N, Price TA, Davis TS, Buckner RL, Rahimpour S, Mickey BJ, Smith EH, Shofty B (2026). Increased Aperiodic Exponents Track Depression Symptom Severity. bioRxiv.
  5. Omelyusik V, Davis TS, Nair SS, Noudoost B, Hackett PD, Smith EH, Rahimpour S, Rolston JD, Kundu B (2026). Frontotemporal bursting supports human working memory. Neuroimage, 327, 121718.
  6. Campbell JM, Cowan RL, Wahlstrom KL, Hollearn MK, Jensen D, Davis T, Rahimpour S, Shofty B, Arain A, Rolston JD, Hamann S, Wang S, Eisenman LN, Swift J, Xie T, Brunner P, Manns J, Inman C, Smith EH, Willie JT (2025). Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala. Elife, 14.
  7. Cowan RL, Davis TS, Merricks EM, Kundu B, Shofty B, Rahimpour S, Schevon CA, Rolston JD, Smith EH (2025). Cell-type-specific responses to single-pulse electrical stimulation of the human brain. Brain Stimul, 18(4), 1266-1278.
  8. Omelyusik V, Davis TS, Nair SS, Noudoost B, Hackett PD, Smith EH, Rahimpour S, Rolston JD, Kundu B (2025). Frontotemporal bursting supports human working memory. bioRxiv.
  9. Norby JH, Hummel D, Ricks N, Rolston J, Rahimpour S, Cowan R, Voipio J, Trevelyan AJ, Smith EH, Parrish RR (2025). Rodent and human seizures demonstrate a dynamic interplay with spreading depolarizations. Neurobiol Dis, 211, 106937.
  10. Campbell JM, Davis TS, Anderson DN, Arain A, Davis ZW, Inman CS, Smith EH, Rolston JD (2025). Macroscale Traveling Waves Evoked by Single-Pulse Stimulation of the Human Brain. J Neurosci, 45(21).
  11. Trevelyan AJ, Marks VS, Graham RT, Denison T, Jackson A, Smith EH (2025). On brain stimulation in epilepsy. Brain, 148(3), 746-752.
  12. Zarr VM, Liou JY, Merricks EM, Davis TS, Thomson K, Greger B, House PA, Emerson RG, Goodman RR, McKhann GM 2nd, Sheth SA, Schevon CA, Rolston JD, Smith EH (2025). Protocol for detecting and analyzing non-oscillatory traveling waves from high-spatiotemporal-resolution human electrophysiological recordings. STAR Protoc, 6(1), 103659.
  13. Cao R, Brunner P, Chakravarthula PN, Wahlstrom KL, Inman C, Smith EH, Li X, Mamelak AN, Brandmeir NJ, Rutishauser U, Willie JT, Wang S (2025). A neuronal code for object representation and memory in the human amygdala and hippocampus. Nat Commun, 16(1), 1510.
  14. Campbell JM, Cowan RL, Wahlstrom KL, Hollearn MK, Jensen D, Davis T, Rahimpour S, Shofty B, Arain A, Rolston JD, Hamann S, Wang S, Eisenman LN, Swift J, Xie T, Brunner P, Manns JR, Inman CS, Smith EH, Willie JT (2024). Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala. bioRxiv.
  15. Yearley AG, Smith EH, Davis TS, Anderson D, Arain AM, Rolston JD (2024). Interictal discharge traveling waves recorded from stereoelectroencephalography electrodes. J Neurosurg, 141(4), 1115-1123.
  16. Campbell JM, Davis TS, Anderson DN, Arain A, Davis Z, Inman CS, Smith EH, Rolston JD (2024). Macroscale traveling waves evoked by single-pulse stimulation of the human brain. bioRxiv.
  17. Charlebois CM, Anderson DN, Smith EH, Davis TS, Newman BJ, Peters AY, Arain AM, Dorval AD, Rolston JD, Butson CR (2024). Circadian changes in aperiodic activity are correlated with seizure reduction in patients with mesial temporal lobe epilepsy treated with responsive neurostimulation. Epilepsia, 65(5), 1360-1373.
  18. Cowan RL, Davis T, Kundu B, Rahimpour S, Rolston JD, Smith EH (2024). More widespread and rigid neuronal representation of reward expectation underlies impulsive choices. bioRxiv.
  19. Caston RM, Smith EH, Davis TS, Singh H, Rahimpour S, Rolston JD (2023). Characterization of spatiotemporal dynamics of binary and graded tonic pain in humans using intracranial recordings. PLoS One, 18(10), e0292808.
  20. Anderson DN, Charlebois CM, Smith EH, Davis TS, Peters AY, Newman BJ, Arain AM, Wilcox KS, Butson CR, Rolston JD (2023). Closed-loop stimulation in periods with less epileptiform activity drives improved epilepsy outcomes. Brain, 147(2), 521-531.
  21. Herman AB, Smith EH, Schevon CA, Yates MJ, McKhann GM, Botvinick M, Hayden BY, Sheth SA (2023). Pretrial predictors of conflict response efficacy in the human prefrontal cortex. iScience, 26(11), 108047.
  22. Caston RM, Smith EH, Davis TS, Singh H, Rahimpour S, Rolston JD (2023). Characterization of spatiotemporal dynamics of binary and graded tonic pain in humans using intracranial recordings. bioRxiv.
  23. Caston RM, Davis TS, Smith EH, Rahimpour S, Rolston JD (2022). A novel thermoelectric device integrated with a psychophysical paradigm to study pain processing in human subjects. J Neurosci Methods, 386, 109780.
  24. Myers JC, Smith EH, Leszczynski M, OSullivan J, Yates MJ, McKhann G, Mesgarani N, Schroeder C, Schevon C, Sheth SA (2022). The Spatial Reach of Neuronal Coherence and Spike-Field Coupling across the Human Neocortex. J Neurosci, 42(32), 6285-6294.
  25. Haegens S, Pathak YJ, Smith EH, Mikell CB, Banks GP, Yates M, Bijanki KR, Schevon CA, McKhann GM, Schroeder CE, Sheth SA (2021). Alpha and broadband high-frequency activity track task dynamics and predict performance in controlled decision-making. Psychophysiology, 59(5), e13901.
  26. Davis TS, Caston RM, Philip B, Charlebois CM, Anderson DN, Weaver KE, Smith EH, Rolston JD (2022). Corrigendum: LeGUI: A Fast and Accurate Graphical User Interface for Automated Detection and Anatomical Localization of Intracranial Electrodes. Front Neurosci, 16, 858978.
  27. Smith EH, Liou JY, Merricks EM, Davis T, Thomson K, Greger B, House P, Emerson RG, Goodman R, McKhann GM, Sheth S, Schevon C, Rolston JD (2022). Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges. Elife, 11.
  28. Anderson DN, Charlebois CM, Smith EH, Arain AM, Davis TS, Rolston JD (2021). Probabilistic comparison of gray and white matter coverage between depth and surface intracranial electrodes in epilepsy. Sci Rep, 11(1), 24155.
  29. Davis TS, Caston RM, Philip B, Charlebois CM, Anderson DN, Weaver KE, Smith EH, Rolston JD (2021). LeGUI: A Fast and Accurate Graphical User Interface for Automated Detection and Anatomical Localization of Intracranial Electrodes. Front Neurosci, 15, 769872.
  30. Edward M Merricks, Elliot H Smith, Ronald G Emerson, Lisa M Bateman, Guy M McKhann, Robert R Goodman, Sameer A Sheth, Bradley Greger, Paul A House, Andrew J Trevelyan, Catherine A Schevon (2021). Neuronal firing and waveform alterations through ictal recruitment in humans. J Neurosci.
  31. Merricks EM, Smith EH, Emerson RG, Bateman LM, McKhann GM, Goodman RR, Sheth SA, Greger B, House PA, Trevelyan AJ, Schevon CA (2020). Neuronal Firing and Waveform Alterations through Ictal Recruitment in Humans. J Neurosci, 41(4), 766-779.
  32. Catherine A Schevon Elliot H Smith, Edward M Merricks, Jyun-You Liou, Camilla Casadei, Lucia Melloni, Thomas Thesen, Daniel J Friedman, Werner K Doyle, Ronald G Emerson, Robert R Goodman, Guy M McKhann II, Sameer A Sheth, John D Rolston (2020). Dual mechanisms of ictal high frequency oscillations in human rhythmic onset seizures. Sci Rep.
  33. Smith EH, Merricks EM, Liou JY, Casadei C, Melloni L, Thesen T, Friedman DJ, Doyle WK, Emerson RG, Goodman RR, McKhann GM 2nd, Sheth SA, Rolston JD, Schevon CA (2020). Dual mechanisms of ictal high frequency oscillations in human rhythmic onset seizures. Sci Rep, 10(1), 19166.
  34. Bornali Kundu, Tyler S Davis, Brian Philip, Elliot H Smith, Amir Arain, Angela Peters, Blake Newman, Christopher R Butson, John D Rolston (2020). A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy. Brain Stimul.
  35. Kundu B, Davis TS, Philip B, Smith EH, Arain A, Peters A, Newman B, Butson CR, Rolston JD (2020). A systematic exploration of parameters affecting evoked intracranial potentials in patients with epilepsy. Brain Stimul, 13(5), 1232-1244.
  36. Abhinav Goyal, Jonathan Miller, Salman E Qasim, Andrew J Watrous, Honghui Zhang, Joel M Stein, Cory S Inman, Robert E Gross, Jon T Willie, Bradley Lega, Jui-Jui Lin, Ashwini Sharan, Chengyuan Wu, Michael R Sperling, Sameer A Sheth, Guy M McKhann, Elliot H Smith, Catherine Schevon, Joshua Jacobs (2020). Functionally distinct high and low theta oscillations in the human hippocampus. Nat Commun.
  37. Goyal A, Miller J, Qasim SE, Watrous AJ, Zhang H, Stein JM, Inman CS, Gross RE, Willie JT, Lega B, Lin JJ, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Jacobs J (2020). Functionally distinct high and low theta oscillations in the human hippocampus. Nat Commun, 11(1), 2469.
  38. Jyun-you Liou, Elliot H Smith, Lisa M Bateman, Samuel L Bruce, Guy M McKhann, Robert R Goodman, Ronald G Emerson, Catherine A Schevon, LF Abbott (2020). A model for focal seizure onset, propagation, evolution, and progression. Elife.
  39. Liou JY, Smith EH, Bateman LM, Bruce SL, McKhann GM, Goodman RR, Emerson RG, Schevon CA, Abbott LF (2020). A model for focal seizure onset, propagation, evolution, and progression. Elife, 9.
  40. Melina Tsitsiklis, Jonathan Miller, Salman E Qasim, Cory S Inman, Robert E Gross, Jon T Willie, Elliot H Smith, Sameer A Sheth, Catherine A Schevon, Michael R Sperling, Ashwini Sharan, Joel M Stein, Joshua Jacobs (2020). Single-neuron representations of spatial targets in humans. Curr Biol.
  41. Tsitsiklis M, Miller J, Qasim SE, Inman CS, Gross RE, Willie JT, Smith EH, Sheth SA, Schevon CA, Sperling MR, Sharan A, Stein JM, Jacobs J (2020). Single-Neuron Representations of Spatial Targets in Humans. Curr Biol, 30(2), 245-253.e4.
  42. James OSullivan, Jose Herrero, Elliot Smith, Catherine Schevon, Guy M McKhann, Sameer A Sheth, Ashesh D Mehta, Nima Mesgarani (2019). Hierarchical encoding of attended auditory objects in multi-talker speech perception. Neuron.
  43. Salman E Qasim, Jonathan Miller, Cory S Inman, Robert E Gross, Jon T Willie, Bradley Lega, Jui-Jui Lin, Ashwini Sharan, Chengyuan Wu, Michael R Sperling, Sameer A Sheth, Guy M McKhann, Elliot H Smith, Catherine Schevon, Joel M Stein, Joshua Jaco (2019). Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex. Nat Neurosci.
  44. Qasim SE, Miller J, Inman CS, Gross RE, Willie JT, Lega B, Lin JJ, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Stein JM, Jacobs J (2019). Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex. Nat Neurosci, 22(12), 2078-2086.
  45. Hannah E Goldstein, Elliot H Smith, Robert E Gross, Barbara C Jobst, Bradley C Lega, Michael R Sperling, Gregory A Worrell, Kareem A Zaghloul, Paul A Wanda, Michael J Kahana, Daniel S Rizzuto, Catherine A Schevon, Guy M McKhann, Sameer A Sheth (2019). Risk of seizures induced by intracranial research stimulation: analysis of 770 stimulation sessions. J Neural Eng.
  46. Goldstein HE, Smith EH, Gross RE, Jobst BC, Lega BC, Sperling MR, Worrell GA, Zaghloul KA, Wanda PA, Kahana MJ, Rizzuto DS, Schevon CA, McKhann GM, Sheth SA (2019). Risk of seizures induced by intracranial research stimulation: analysis of 770 stimulation sessions. J Neural Eng, 16(6), 066039.
  47. Elliot H Smith, Guillermo Horga, Mark J Yates, Charles B Mikell, Garrett P Banks, Yagna J Pathak, Catherine A Schevon, Guy M McKhann, Benjamin Y Hayden, Matthew M Botvinick, Sameer A Sheth (2019). Widespread temporal coding of cognitive control in the human prefrontal cortex. Nat Neurosci.
  48. Smith EH, Horga G, Yates MJ, Mikell CB, Banks GP, Pathak YJ, Schevon CA, McKhann GM 2nd, Hayden BY, Botvinick MM, Sheth SA (2019). Widespread temporal coding of cognitive control in the human prefrontal cortex. Nat Neurosci, 22(11), 1883-1891.
  49. Wenzel M, Han S, Smith EH, Hoel E, Greger B, House PA, Yuste R (2019). Reduced Repertoire of Cortical Microstates and Neuronal Ensembles in Medically Induced Loss of Consciousness. Cell Syst, 8(5), 467-474.e4.
  50. Michael Wenzel, Shuting Han, Elliot Smith, Hoel Erik, Bradley Greger, Paul House, Rafael Yuste (2019). Reduced repertoire of cortical microstates and neuronal ensembles in medically-induced loss of consciousness. Cell Syst.
  51. Smith EH, Rolston JD (2018). Oscillations Travel Around the Human Brain. Neurosurgery, 83(5), E205-E206.
  52. Liou JY, Ma H, Wenzel M, Zhao M, Baird-Daniel E, Smith EH, Daniel A, Emerson R, Yuste R, Schwartz TH, Schevon CA (2018). Role of inhibitory control in modulating focal seizure spread. Brain, 141(7), 2083-2097.
  53. Miller J, Watrous AJ, Tsitsiklis M, Lee SA, Sheth SA, Schevon CA, Smith EH, Sperling MR, Sharan A, Asadi-Pooya AA, Worrell GA, Meisenhelter S, Inman CS, Davis KA, Lega B, Wanda PA, Das SR, Stein JM, Gorniak R, Jacobs J (2018). Lateralized hippocampal oscillations underlie distinct aspects of human spatial memory and navigation. Nat Commun, 9(1), 2423.
  54. Liou JY, Smith EH, Bateman LM, McKhann GM, Goodman RR, Greger B, Davis TS, Kellis SS, House PA, Schevon CA (2017). Multivariate regression methods for estimating velocity of ictal discharges from human microelectrode recordings. J Neural Eng, 14(4), 044001.
  55. Smith EH, Liou JY, Davis TS, Merricks EM, Kellis SS, Weiss SA, Greger B, House PA, McKhann GM 2nd, Goodman RR, Emerson RG, Bateman LM, Trevelyan AJ, Schevon CA (2016). The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures. Nat Commun, 7, 11098.
  56. Eissa TL, Tryba AK, Marcuccilli CJ, Ben-Mabrouk F, Smith EH, Lew SM, Goodman RR, McKhann GM Jr, Frim DM, Pesce LL, Kohrman MH, Emerson RG, Schevon CA, van Drongelen W (2016). Multiscale Aspects of Generation of High-Gamma Activity during Seizures in Human Neocortex.LID - 10.1523/ENEURO.0141-15.2016 [doi]LID - ENEURO.0141-15.2016 [pii]. eNeuro, 3(2).
  57. Smith EH, Banks GP, Mikell CB, Cash SS, Patel SR, Eskandar EN, Sheth SA (2015). Frequency-Dependent Representation of Reinforcement-Related Information in the Human Medial and Lateral Prefrontal Cortex. J Neurosci, 35(48), 15827-36.
  58. Merricks EM, Smith EH, McKhann GM, Goodman RR, Bateman LM, Emerson RG, Schevon CA, Trevelyan AJ (2015). Single unit action potentials in humans and the effect of seizure activity. Brain, 138(Pt 10), 2891-906.
  59. McGovern RA, Ratneswaren T, Smith EH, Russo JF, Jongeling AC, Bateman LM, Schevon CA, Feldstein NA, McKhann GM 2nd, Sheth S (2015). Investigating the function of deep cortical and subcortical structures using stereotactic electroencephalography: lessons from the anterior cingulate cortex.LID - 10.3791/52773 [doi]. J Vis Exp, (98).
  60. Smith E, Kellis S, House P, Greger B (2013). Decoding stimulus identity from multi-unit activity and local field potentials along the ventral auditory stream in the awake primate: implications for cortical neural prostheses. J Neural Eng, 10(1), 016010.
  61. Smith E, Duede S, Hanrahan S, Davis T, House P, Greger B (2013). Seeing is believing: neural representations of visual stimuli in human auditory cortex correlate with illusory auditory perceptions. PLoS One, 8(9), e73148.
  62. Smith EH, Kellis SS, House PA, Greger B (2013). Information transfer along the ventral auditory processing stream in the awake macaque. Annu Int Conf IEEE Eng Med Biol Soc, 2012, 5178-81.

Review

  1. Cowan RL, Merricks EM, Davis TS, Rolston JD, Rahimpour S, Shofty B, Schevon CA, Smith EH (2026). Single-neuron responses to neurostimulation: Insights for epilepsy. [Review]. Neurotherapeutics, 23(4), e01031.
  2. Caston RM, Smith EH, Davis TS, Rolston JD (2020). The Cerebral Localization of Pain: Anatomical and Functional Considerations for Targeted Electrical Therapies. [Review]. J Clin Med, 9(6).
  3. Smith EH, Schevon CA (2016). Toward a Mechanistic Understanding of Epileptic Networks. [Review]. Curr Neurol Neurosci Rep, 16(11), 97.
  4. Smith EH (2011). Temporal processing in the auditory core: transformation or segregation? [Review]. J Neurophysiol, 106(6), 2791-3.

Conference Proceedings

  1. Sklar S, Walmer M, Sacre P, Schevon CA, Srinivasan S, Banks GP, Yates MJ, McKhann GM, Sheth SA, Sarma SV, Smith EH (2017). Neuronal activity in human anterior cingulate cortex modulates with internal cognitive state during multi-source interference task. Conf Proc IEEE Eng Med Biol Soc, 2017, 962-65.
  2. Smith EH, Kellis SS, House PA, Greger B (2012). Information transfer along the ventral auditory processing stream in the awake macaque. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Diego, CA, 5178-81.

Abstract

  1. Sheth S, Horga G, Yates M, Pathak Y, Schevon C, McKhann G, Smith E (2017). Neuronal mechanisms of cognitive control in human prefrontal cortex [Abstract]. Neurosurgery.
  2. Dyster TG, Pathak Y, Smith E, Sheth SA (2016). An easily implemented, open access, semi-automated pipeline for intracranial electrode localization [Abstract]. Neurosurgery, 63(CN_suppl_1), 156.
  3. Mikell C, Smith E, Brown L, McKhann G, Sheth S (2014). Spatial Conflict is Encoded in Human MT+ [Abstract]. Neurosurgery.