F. Edward Dudek

F. Edward Dudek, PhD

Languages spoken: English

Academic Information

Departments Primary - Neurosurgery

Dr. Dudek received his B.S. in Biological Sciences from the University of California, Irvine in 1969, as well as his Ph.D. in 1973 from the Department of Developmental and Cell Biology. In Feb. 1973, Dr. Dudek became an NIH postdoctoral fellow in the Department of Ophthalmology Research at Columbia University Medical Center in New York. From April 1974 to September 1974 he was a Postdoctoral Research Associate in the Department of Psychobiology, University of California at Irvine. He was then a Postdoctoral Research Associate at the Marine Biomedical Institute and Department of Physiology and Biophysics at the University of Texas Medical Branch in Galveston, TX from 1974 to 1975.

Dr. Dudek became an Assistant Professor in the Department of Zoology at the University of Toronto in 1975. He moved to the Department of Physiology as an Associate Professor at Tulane University School of Medicine in New Orleans, LA in 1980 and was promoted to Professor in 1984. Dr. Dudek became Professor and Associate Director of the Mental Retardation Research Center at the University of California at Los Angeles School of Medicine in 1987. He moved to become Professor and Chair of the Department of Anatomy and Neurobiology in the College of Veterinary Medicine and Biomedical Sciences at Colorado State University from 1992 to 2000. Dr. Dudek became Professor and Chair of the Department of Physiology at the University of Utah School of Medicine in 2005, and then transferred to the Department of Neurosurgery as Vice Chair for Translational Research in 2012.

Education History

Undergraduate University of California
 BSc
Doctoral Training University of California, Dept. of Developmental and Cell Biology
 PhD
Postdoctoral Training Columbia University, Dept. of Ophthalmology Research, College of Physicians and Surgeons
 Postdoctoral Training
Postdoctoral Training University of California, Dept. of Psychobiology
 Postdoctoral Training
Postdoctoral Training Marine Biomedical Institute and Dept. of Physiology & Biophysics, University of Texas Medical Branch
 Postdoctoral Training

Selected Publications

Journal Article

  1. Dingledine R, Varvel NH, Dudek FE (2014). When and how do seizures kill neurons, and is cell death relevant to epileptogenesis? Adv Exp Med Biol, 813, 109-22. (Read full article)
  2. Sawant-Pokam PM, Suryavanshi P, Mendez JM, Dudek FE, Brennan K (2017). Mechanisms of Neuronal Silencing After Cortical Spreading Depression. Cerebral cortex (New York, N.Y., 27(2), 1311-1325. (Read full article)
  3. Spampanato J, Dudek F (2014). Valnoctamide enhances phasic inhibition: a potential target mechanism for the treatment of benzodiazepine-refractory status epilepticus. Epilepsia, 55(9), e94-8. (Read full article)
  4. Spampanato J, Pouliot W, Bealer SL, Roach B, Dudek F (2019). Antiseizure and neuroprotective effects of delayed treatment with midazolam in a rodent model of organophosphate exposure. Epilepsia, 60(7), 1387-1398. (Read full article)
  5. Zayachkivsky A, Lehmkuhle MJ, Ekstrand JJ, Dudek F (2015). Ischemic injury suppresses hypoxia-induced electrographic seizures and the background EEG in a rat model of perinatal hypoxic-ischemic encephalopathy. Journal of neurophysiology, 114(5), 2753-63. (Read full article)
  6. Rodgers KM, Dudek FE, Barth D (2015). Progressive, Seizure-Like, Spike-Wave Discharges Are Common in Both Injured and Uninjured Sprague-Dawley Rats: Implications for the Fluid Percussion Injury Model of Post-Traumatic Epilepsy. The Journal of neuroscience, 35(24), 9194-204. (Read full article)
  7. Bercum FM, Rodgers KM, Benison AM, Smith ZZ, Taylor J, Kornreich E, Grabenstatter HL, Dudek FE, Barth D (2015). Maternal Stress Combined with Terbutaline Leads to Comorbid Autistic-Like Behavior and Epilepsy in a Rat Model. The Journal of neuroscience, 35(48), 15894-902. (Read full article)
  8. Spampanato J, Bealer SL, Smolik M, Dudek F (2020). Delayed Adjunctive Treatment of Organophosphate-Induced Status Epilepticus in Rats with Phenobarbital, Memantine, or Dexmedetomidine. The Journal of pharmacology and experimental therapeutics, 375(1), 59-68. (Read full article)
  9. Trandafir CC, Pouliot WA, Dudek FE, Ekstrand J (2015). Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. Neuroscience, 284, 601-610. (Read full article)
  10. Kadam SD, Dudek F (2016). Temporal progression of evoked field potentials in neocortical slices after unilateral hypoxia-ischemia in perinatal rats: Correlation with cortical epileptogenesis. Neuroscience, 316, 232-48. (Read full article)
  11. Barker BS, Spampanato J, McCarren HS, Smolik M, Jackson CE, Hornung EN, Yeung DT, Dudek FE, McDonough J (2020). Screening for Efficacious Anticonvulsants and Neuroprotectants in Delayed Treatment Models of Organophosphate-induced Status Epilepticus. Neuroscience, 425, 280-300. (Read full article)
  12. Barker BS, Spampanato J, McCarren HS, Berger K, Jackson CE, Yeung DT, Dudek FE, McDonough J (2021). The Kv7 Modulator, Retigabine, is an Efficacious Antiseizure Drug for Delayed Treatment of Organophosphate-induced Status Epilepticus. Neuroscience, 463, 143-158.
  13. Pouliot W, Bealer SL, Roach B, Dudek F (2016). A rodent model of human organophosphate exposure producing status epilepticus and neuropathology. Neurotoxicology, 56, 196-203. (Read full article)
  14. Zayachkivsky A, Lehmkuhle MJ, Dudek F (2015). Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System. Journal of visualized experiments, (101), e52554. (Read full article)
  15. Johnstone TBC, McCarren HS, Spampanato J, Dudek FE, McDonough JH, Hogenkamp D, Gee K (2019). Enaminone Modulators of Extrasynaptic ¿4ß3¿ ¿-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning. Frontiers in pharmacology, 10, 560. (Read full article)
  16. Pitkanen A, Lukasiuk K, Dudek FE, Staley K (2015). Epileptogenesis.LID - 10.1101/cshperspect.a022822 [doi]LID - a022822 [pii]. Cold Spring Harbor perspectives in medicine, 5(10), (Read full article)
  17. Barker BS, Spampanato J, McCarren HS, Berger K, Jackson CE, Yeung DT, Dudek FE, McDonough J (2021). The K(v)7 Modulator, Retigabine, is an Efficacious Antiseizure Drug for Delayed Treatment of Organophosphate-induced Status Epilepticus. Neuroscience, 463, 143-158. (Read full article)
  18. Tatum S, Smith ZZ, Taylor JA, Poulsen DJ, Dudek FE, Barth D (2021). Sensitivity of unilateral- versus bilateral-onset spike-wave discharges to ethosuximide and carbamazepine in the fluid percussion injury rat model of traumatic brain injury. Journal of neurophysiology, 125(6), 2166-2177. (Read full article)
  19. Zayachkivsky A, Lehmkuhle MJ, Ekstrand JJ, Dudek F (2022). Background suppression of electrical activity is a potential biomarker of subsequent brain injury in a rat model of neonatal hypoxia-ischemia. Journal of neurophysiology, 128(1), 118-130. (Read full article)
  20. Shao LR, Dudek F (2022). Enhanced burst discharges in the CA1 area of the immature versus adult hippocampus: patterns and cellular mechanisms. Journal of neurophysiology, 128(6), 1566-1577. (Read full article)
  21. Bertram EH, Dudek F (2024). Addressing the problems of treatment failure in epilepsy: You cannot fix what you do not understand. Epilepsia, 65(8), 2248-2254. (Read full article)
  22. Sawant-Pokam PM, Zayachkivsky A, Grabenstatter H, Brennan KC, Dudek F (2025). Pathophysiological levels of extracellular calcium and potassium induce seizure-like discharges: identification of synaptic and non-synaptic components. Journal of neurophysiology, 134(4), 1153-1173. (Read full article)