Jonathan E. Constance

Jonathan E. Constance, PhD

Languages spoken: English

Academic Information

Departments Primary - Pediatrics

Divisions: Clinical Pharmacology

Board Certification

  • American Board of Clinical Pharmacology

Dr. Constance’s NIH-funded laboratory is focused on using population-specific pharmacokinetic data to better understand the potential risk for and consequences of drug interactions in children with cancer. A major emphasis is on understanding the mechanistic basis for drug interactions that can alter chemotherapeutic activity. By employing a variety of molecular biology approaches, ‘real world’ drug concentration data can be applied to clinically relevant models of cancer to better understand where resistance can occur. We maintain an active pediatric-cancer focused biorepository to facilitate the collection and analysis of specimens to obtain pharmacokinetic and biomarker data. Our biorepository is comprised of thousands of samples collected from hundreds of unique children diagnosed with cancer. These pharmacokinetic and biomarker data are used in modeling and simulation approaches to inform pharmacodynamic and in vitro molecular biologic studies. Our lab can provide training which spans basic molecular biology techniques, such as cell culture and genetic engineering, to clinical pharmacokinetics.

Education History

Fellowship University of Utah
 Research Fellow
Postdoctoral Fellowship University of Utah
 Clinical Fellow
Doctoral Training University of Utah
 PhD
Undergraduate University of Utah
 BS

Selected Publications

Journal Article

  1. Rower JE, King AD, Wilkins D, Wilkes J, Yellepeddi V, Maese L, Lemons RS, Constance JE (2020). Dronabinol Prescribing and Exposure Among Children and Young Adults Diagnosed with Cancer. J Adolesc Young Adult Oncol, 10(2), 175-184.
  2. Yellepeddi VK, Parashar K, Dean SM, Watt KM, Constance JE, Baker OJ (2020). Predicting Resolvin D1 Pharmacokinetics in Humans with Physiologically-Based Pharmacokinetic Modeling. Clin Transl Sci, 14(2), 683-691.
  3. Biltaji E, Enioutina EY, Yellepeddi V, Rower JE, Sherwin CMT, Ward RM, Lemons RS, Constance JE (2020). Supportive care medications coinciding with chemotherapy among children with hematologic malignancy. Leuk Lymphoma, 61(8), 1920-1931.

News & Podcasts

Huntsman Cancer Institute News