Shami Kanekar

Shami Kanekar, PhD

Languages spoken: English

Academic Information

Departments Primary - Psychiatry

Divisions: Adult Psychiatry

Education History

Undergraduate University of Bombay
 BSc
Graduate Training University of Bombay
 MSc
Doctoral Training University of Iowa Neuroscience Program
 PhD
Postdoctoral Fellowship La Jolla Cancer Research Foundation
 Postdoctoral Fellow
Fellowship University of Utah, Department of Physiology
 Postdoctoral Fellow

Selected Publications

Journal Article

  1. Bogdanova OV, Abdullah O, Kanekar S, Bogdanov VB, Prescot AP, Renshaw P (2014). Neurochemical Alterations in the Frontal Cortex of the rat after one week of hypobaric hypoxia. Behavioural brain research, 263(263), 203-209.
  2. Kanekar S, Perron M, Dorsky R, Harris WA, Jan LY, Jan YN, Vetter M (1997). Xath5 participates in a network of bHLH genes in the developing Xenopus retina. Neuron, 19(5), 981-94.
  3. Perron M, Kanekar S, Vetter ML, Harris W (1998). The genetic sequence of retinal development in the ciliary margin of the Xenopus eye. Developmental biology, 199(2), 185-200.
  4. Brown NL, Kanekar S, Vetter ML, Tucker PK, Gemza DL, Glaser (1998). Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis. Development (Cambridge, England), 125(23), 4821-33.
  5. Kanekar S, Ritchie TC, Coulter J (1993). Spinal cord afferent systems containing the nerve terminal protein NT75. The Journal of comparative neurology, 332(2), 198-212.
  6. Kanekar S, Jia C, Hegg C (2009). Purinergic receptor activation evokes neurotrophic factor neuropeptide Y release from neonatal mouse olfactory epithelial slices. Journal of neuroscience research, 87(6), 1424-34.
  7. Kanekar S, Sheth CS, Olson PR, Bogdanova OV, Ombach H, M Petersen, Renshaw CE, Sung YH, D'Anci KE, Renshaw, P (2018). Hypobaric Hypoxia Exposure in Rats Differentially Alters Antidepressant Efficacy of the Selective Serotonin Reuptake Inhibitors Fluoxetine, Paroxetine, Escitalopram and Sertraline. Pharmacology, biochemistry, and behavior, 170, 25-35.
  8. Kanekar S, Sheth C, Ombach H, Brown J, Hoffman M, Ettaro R, Renshaw (2021). Sex-based changes in rat brain serotonin and behavior in a model of altitude-related vulnerability to treatment-resistant depression. Psychopharmacology, 238, 2867-2881.
  9. Kanekar S, Gandham M, Lucero M (2010). PACAP protects against TNFalpha-induced cell death in olfactory epithelium and olfactory placodal cell lines. Molecular and cellular neurosciences, 45(4), 345-54.
  10. Hartmann JS, Thompson H, Wang H, Kanekar S, Huang W, Budd SJ, Hartnett M (2011). Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity. Molecular vision, 17, 1577-87.
  11. Tucker P, Laemle L, Munson A, Kanekar S, Oliver ER, Brown N, Schlecht H, Vetter M, Glaser (2001). The eyeless mouse mutation (ey1) removes an alternative start codon from the Rx/rax homeobox gene. Genesis (New York, N.Y., 31(1), 43-53.
  12. Sun Y, Kanekar SL, Vetter ML, Gorski S, Jan YN, Glaser T, Brown N (2003). Conserved and divergent functions of Drosophila atonal, amphibian, and mammalian Ath5 genes. Evolution & development, 5(5), 532-41.
  13. Sheth CS, Ombach HJ, Olson PR, Renshaw PF, & Kanekar (2018). Increased Anxiety And Anhedonia In Female Rats Following Exposure To Altitude. High altitude medicine & biology, 19(1), 81-90.
  14. Kanekar S, Bogdanova OV, Olson PR, Sung YH, D'Anci KE, Renshaw P (2015). Hypobaric Hypoxia induces Depression-like Behavior in Female Sprague Dawley Rats, but not in Males. High altitude medicine & biology, 16(1), 52-60.
  15. Ombach HJ, Scholl LS, Bakian AV, Renshaw KT, Sung YH, Renshaw PF, & S Kaneka (2019). Association Between Altitude, Prescription Opioid Misuse, and Fatal Overdoses. Addictive behaviors reports, 9, 1000167.
  16. Kanekar S, Ettaro R, Hoffman MD, Ombach HJ, Brown J, Lynch C, Sheth CS, Renshaw P (2021). Sex-Based Impact of Creatine Supplementation on Depressive Symptoms, Brain Serotonin and SSRI Efficacy in an Animal Model of Treatment-Resistant Depression. International journal of molecular sciences, 22(15),
  17. Prescot A, Huber R, Kanekar S, Kondo D, Prisciandaro J, Ongur D, Renshaw P (2021). Effect of moderate altitude on human cerebral metabolite levels: A preliminary, multi-site, proton magnetic resonance spectroscopy investigation. Psychiatry research. Neuroimaging, 314, 111314.
  18. R Ettaro, MD Hoffman, HJ Ombach, J Brown, CS Sheth, K Jessing, P Sebahar, PF Renshaw and S Kaneka The creatine-analog cyclocreatine improves brain bioenergetics and exhibits antidepressant-like activity in a model of SSRI-resistant depression. Psychopharmacology,

Review

  1. Bogdanova OV, Kanekar S, D'Anci K, Renshaw P (2013). Factors influencing behavior in the forced swim test. Physiology & behavior, 118, 227-239.
  2. Gould TD, Georgiou P, Brenner LA, Brundin L, Can A, Courtet P, Donaldson Z, Dwivedi Y, Guillaume S, Gottesman II, Kanekar S, Lowry C, Renshaw PF, Rujescu D, Smith E, Turecki G, Zanos P, Zarate CA, Zunszain PA, Postolache T (2017). Animal Models to Improve our Understanding and Treatment of Suicidal Behavior. Translational psychiatry, 7(4), 1-22.
  3. Kanekar S and Renshaw P (2019). The Impact of Living at Altitude on Depression and Antidepressant Function in Utah Women: The Need for Novel Antidepressants. The Utah women's health review, 2019, 1-20.

Book Chapter

  1. Kanekar S (2024). Creatine in Neuroprotection and Neurotoxicity.

Conference Proceedings

  1. Kanekar S, Bogdanova OV, Olson PR, Renshaw CE, Sung YH, D'Anci KE, Renshaw, P (2015). Antidepressant Efficacy in a Rodent Model of Hypoxia-Related Depression: Do SSRIs Lose Efficacy at Altitude? American College of Neuropsychopharmacology meeting, Hollywood, FL. Neuropsychopharmacology, 40, S334.
  2. CS Sheth, HJ Ombach, J Brown, PF Renshaw, and S Kanekar (2018). Living at Moderate Altitude May Alter Brain Monoamines to Worsen Mood and Substance Use Disorders: A Sex-based Animal Model Study. American College of Neuropsychopharmacology meeting, Hollywood, FL. Neuropsychopharmacology, 43, S69.
  3. HJ Ombach, LS Scholl, AV Bakian, KT Renshaw, YH Sung, PF Renshaw and S Kaneka (2018). Living at Altitude is an Independent Risk Factor for Increased Prescription Opioid Misuse and Fatal Overdose by Prescription Opioids. American College of Neuropsychopharmacology meeting, Hollywood, FL. Neuropsychopharmacology, 43, S132.
  4. Kanekar S, Bogdanova OV, Olson PR, Nizam H, Ombach HJ, Renshaw CE, Sung Y, D'Anci KE, and Renshaw, P (2015). Methamphetamine preference in female rats in the conditioned place preference test increases at altitude. American College of Neuropsychopharmacology meeting, Hollywood, FL. Neuropsychopharmacology, 40, S424.
  5. Kanekar S, Sheth CS, Olson PR, M Petersen, Bogdanova OV, Renshaw CE, Sung YH, D'Anci KE, Renshaw, P (2016). Differential Effects of the SSRIs Fluoxetine, Paroxetine, Escitalopram and Sertraline in a Rodent Model of Hypobaric Hypoxia-related Depression. American College of Neuropsychopharmacology meeting, Hollywood, FL. Neuropsychopharmacology, 41, S163.
  6. Kanekar S, Hegg CC, Lucero M (2007). PACAP-38 reduces cytokine-induced ROS production and apoptosis in the olfactory epithelium by a PAC1-receptor mediated mechanism. 8th International Symposium for VIP, PACAP and Related Peptides, Manchester, VT. Journal of molecular neuroscience,
  7. Brown NL, Kanekar S, Vetter ML, Tucker PK, Gemza DL, Glazer (1998). Math5 encodes a murine basic helix -loop-helix transcription factor expressed during early stages of retinal neurogenesis. 14th In Congress of Developmental Biology, Palo Alto, CA. Developmental biology,
  8. Kanekar S, Perron M, Dorsky R, Harris WA, Jan LY, Jan YN, Vetter M (1997). Xath5, a Xenopus homolog of the Drosophila proneural gene atonal, functions with Xash3 and NeuroD to regulate neurogenesis.13th International Congress of Developmental Biology, Snowbird, Utah. Developmental biology,
  9. Lucero MT, Kanekar (2008). PACAP reduces cytokine-induced apoptosis in olfactory neuronal cells via both AC and PLC pathways. XVth International Symposium on Olfaction and Taste, San Francisco, CA.
  10. Kanekar S, Ranscht (1992). Expression of T-cadherin in the floor plate correlates with commissural axon growth across the ventral midline of the spinal cord. Society for Neuroscience meeting, Anaheim, CA.
  11. SE Smith, S Kanekar, J Lee, AD Plante, PF Renshaw, MB Scholan (2017). Characterization of shared molecular pathways in idiopathic pulmonary fibrosis and depression.
  12. Lucero MT, Hegg CC, Kanekar (2007). PACAP-38 reduces Ros production and apoptosis in the olfactory epithelium by a PAC1 receptor-mediated mechanism. Association of Chemoreception Senses Annual Meeting, Sarasota, FL.
  13. Kanekar S, Hegg C (2007). Purinergic receptor activation evokes neurotrophic factor Y release from mouse olfactory epithelial slices. Society for Experimental Biology Annual Meeting, Washington DC.
  14. Kanekar S, Hegg C (2006). Purinergic receptor activation evokes NPY release from mouse olfactory epithelial slices. Association of Chemoreception Senses Annual Meeting, Sarasota, FL.
  15. Kanekar S, Ritchie TC, Coulter J (1991). Peripheral inflammation induces expression of the nerve terminal protein NT75 in spinal neurons. Society for Neuroscience meeting, New Orleans, LA.
  16. Kanekar S, Sheth CS, Ombach HJ, Olson PR, Bogdanova OV, Petersen M, Renshaw CE, Sung YH, D'Anci KE, & Renshaw P (2019). Improving Brain Bioenergetics may Improve Altitude-related Depression: Animal Model Studies. American College of Neuropsychopharmacology meeting, Orlando, FL. 44, M139.
  17. Kanekar S (2020). An Animal Model for SSRI-Resistant Depression at Altitude: Brain Serotonin and Antidepressants Based on Bioenergetics. Talk for Panel on “Sex Differences in Depression: focus on factors that differentially affect females or males” session. American College of Neuropsychopharmacology virtual meeting. 45, 1-67.
  18. Kanekar S., R Ettaro, MD Hoffman, HJ Ombach, J Brown, CS Sheth, K Jessing, P Sebahar, and PF Rensha (2021). Cyclocreatine: a bioenergetic molecule which improves depression-like and anxiety-like behaviors in an animal model of SSRI-resistant depression at altitude. American College of Neuropsychopharmacology meeting, San Juan, PR. 46, 255.
  19. Vetter ML, Kanekar S (1997). Xath, a Xenopus Atonal homolog, is a positive regulator of retinal differenciation. Investigative Ophthamology and Visual Science meeting, Fort Lauderdale, FL. 38(4), 4330-4330.

Abstract

  1. Kanekar S, Bogdanova OV, Olson PR, D'Anci KE, Sung YH, Renshaw P (2014). Hypobaric hypoxia induces DLB and alters SSRI efficacy in female Sprague Dawley rats.
  2. S. Kanekar, H.J. Ombach, J. Brown, M.D. Hoffman, R.E. Ettaro, C.S. Sheth, Y.H. Sung and P.F. Rensha (2020). Therapeutics Targeting Brain Bioenergetics may be Effective as Antidepressants in Altitude-related Treatment-Resistant Depression: Sex-based Animal Model Studies.
  3. S. Kanekar, R.E. Ettaro, M.D. Hoffman and P.F. Rensha (2021). Sex-based animal model studies identifying effective therapeutics for treatment-resistant depression at altitude.
  4. S. Kanekar, R.E. Ettaro, M.D. Hoffman and P.F. Rensha (2021). Methamphetamine rewards and brain dopamine may increase with housing at moderate altitude in females: sex-based animal model studies.
  5. Kanekar S., R Ettaro and PF Rensha (2022). Housing rats at moderate altitude causes systemic inflammation and alters cognitive behavior.
  6. S. Kanekar, RE Ettaro and PF Rensha (2021). Sex-based animal model studies identifying effective therapeutics for SSRI-resistant depression at altitude.
  7. PF Renshaw, R. Ettaro and Kanekar S (2022). Housing rats at moderate altitude increases depressive symptoms, causes systemic inflammation and alters cognitive behavior.
  8. Ettaro R., Kanekar S., M.D. Hoffman, H.J. Ombach, J. Brown, C.S. Sheth, K. Jessing, P. Sebahar and P.F. Rensha (2022). Cyclocreatine: a bioenergetic molecule which improves depression- and anxiety-like behaviors in an animal model of SSRI-resistant depression.
  9. Kanekar S., Ettaro R. and P.F. Rensha (2022). An Animal Model for Altitude-related Depression and Anxiety Disorders: Women may be more Vulnerable to Hypoxic Stress.
  10. S Kanekar, R Ettaro and PF Rensha (2024). Hypobaric hypoxia induces depressive, anxiety and cognitive symptoms in rats, with females more vulnerable. Meeting of the Organization of the Study of Sex Differences.
  11. S. Kanekar, R. Ettaro, PF Rensha (2024). Housing at moderate altitude induces depressive, anxiety and cognitive symptoms in a rodent model, with females particularly vulnerable. Meeting of the University of Utah's Women's Health Center of Excellence.
  12. RE Ettaro, MD Hoffman, R Amin, PF Renshaw and S Kanekar (2025) Housing at moderate altitude increases striatal dopamine levels and elevates methamphetamine preference in female rats, but not males. [Poster]. Conference of the University of Utah Women’s Health Center of Excellence.